Effects of Testosterone and Castration on Cholesteremia and Atherogenesis in Chicks on High Fat, High Cholesterol Diets

نویسنده

  • Philip Johnson
چکیده

IT IS a well documented fact that a significant sex differential exists in severity of coronary atherosclerosis and incidence of coronary heart disease in middle-aged human beings." Considerable evidence is available to indicate that ovarian estrogen secretion is a key factor in protection of premenopansal women from this disease. ~ Little evidence is available concerning the relationship of androgenic secretion to the development of coronary atherosclerosis. Previous experiments in this laboratory have explored this set of problems, particularly with reference to the role of ovarian estrogen secretion. It was demonstrated that mature hens—in contrast to roosters—are remarkably resistant to cholesterol-induced coronary atherogenesis." Ovariectomy abolished this "immunity." It was also shown that estrogen administration protected male chicks against cholesterol-induced coronary atherosclerosis. This series of studies lent significant experimental support to the hypothesis that estrogenic secretion is a key factor in the immunity of premenopausal women to coronary disease.

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Effects of testosterone and castration on cholesteremia and atherogenesis in chicks on high fat, high cholesterol diets.

IT IS a well documented fact that a significant sex differential exists in severity of coronary atherosclerosis and incidence of coronary heart disease in middle-aged human beings." Considerable evidence is available to indicate that ovarian estrogen secretion is a key factor in protection of premenopansal women from this disease. ~ Little evidence is available concerning the relationship of an...

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تاریخ انتشار 2005